Research on Irradiation Uniformity Optimization of High-Voltage Power Supplies for Blood Irradiation Systems

Blood irradiation technology, as a critical method for preventing transfusion-related complications, relies fundamentally on the radiation field uniformity governed by high-voltage power supply performance. This paper systematically analyzes key technological pathways for improving irradiation uniformity through radiation field optimization, dynamic compensation mechanisms, and calibration systems, incorporating advanced materials and intelligent algorithms. 

1. Radiation Field Modeling and Optimization 
Modern blood irradiation devices employ isocentric radiation field designs, where uniformity is significantly influenced by high-voltage power supply parameters: 
1. Voltage Waveform Stability: Output ripple must be controlled within 0.5% to prevent X-ray energy dispersion caused by voltage fluctuations 
2. Multi-focus Collaborative Irradiation: Phase modulation of three independent high-voltage modules creates superimposed radiation fields, reducing dose inhomogeneity from ±25% to ±8% 
3. Monte Carlo Simulation: Geant4-based mass attenuation modeling of blood components optimizes electron beam incidence angles and energy distribution, achieving a 1:13 dose ratio between erythrocytes and lymphocytes 

2. Dynamic Dose Compensation Technology 
To address irradiation shadows caused by blood bag deformation, two generations of compensation systems have been developed: 
1. Mechanical Compensation: Six-axis robotic arms with real-time density sensing achieve 0.1mm positioning accuracy but suffer from 200ms latency 
2. Electron Beam Scanning Compensation: Magnetic deflection coupled with pulse-width modulation enables dose gradient reconstruction within 10ms, reducing localized overdosing by 72% 

3. Full-lifecycle Calibration System 
A three-tier calibration network ensures irradiation uniformity: 
1. Primary Standardization: Annual dose distribution verification using tissue-equivalent phantoms and thermoluminescent dosimeters (TLD) 
2. Online Monitoring: Embedded PIN diode arrays provide real-time dose mapping at 0.5cGy resolution 
3. AI-driven Correction: Convolutional neural network (CNN) models automatically compensate edge attenuation zones with 3-5 additional pulse cycles 

4. Thermal Stability and EMI Mitigation 
1. Dual-cycle Thermal Management: Phase-change materials (PCM) combined with microchannel liquid cooling limit temperature drift to ±0.3℃/h 
2. EMI Shielding: Multi-layer μ-metal shielding reduces external electromagnetic interference by 40dB 
3. Vibration Suppression: Active air spring isolation platforms constrain beam displacement caused by mechanical vibrations to 50μm 

Conclusion: Enhancing blood irradiation uniformity requires a closed-loop system integrating power supply precision, radiation field control, and intelligent compensation. Future advancements will focus on multi-physics coupling simulations, 2D photon-counting detector integration, and digital twin-based real-time optimization systems to elevate clinical transfusion safety standards.